Jill P. Mesirov, Ph.D.

UC San Diego, School of Medicine
UC San Diego, Moores Cancer Center

Professor of Medicine, Division of Medical Genetics;
Associate Vice Chancellor for Computational Health Sciences;
Co-Lead, Structural and Functional Cancer Genomics Research Program;

Learn More...

Research in the Mesirov Lab focuses on cancer genomics applying machine-learning methods to functional data derived from patient tumors. The lab analyzes these molecular data to determine the underlying biological mechanisms of specific tumor subtypes, to stratify patients according to their relative risks of relapse, and to identify candidate compounds for new treatments. The overall goal is to treat patients as individuals specific to their tumors. Importantly, the lab is committed to the development of practical, accessible software tools to bring these methods to the general biomedical research community. The tools support over 900,000 users worldwide.

Featured Publications

Featured Publications

    2022

    • Do M, Wu CCN, Sonavane PR, Juarez EF, Adams SR, Ross J, Rodriguez YBA, Patel C, Mesirov JP, Carson DA, Advani SJ, Willert K. A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models. Mol Cancer Ther. 2022;21(1):113-24. Epub 20211019. doi: 10.1158/1535-7163.MCT-21-0548. PubMed PMID: 34667113; PMCID: PMC8742765.

    2021

    • Sharma AK, de la Torre J, NS IJ, Sutton TL, Zhao B, Khan TM, Banerjee S, Cui C, Nguyen V, Alkhuziem M, Snaebjornsson P, van Boven H, Bruining A, Tang CM, Yoon H, De la Fuente A, Kato S, Patel H, Heinrich MC, Corless CL, Horgan S, Burgoyne AM, Fanta P, Mesirov JP, Blakely AM, Davis JL, Mayo SC, van Houdt WJ, Steeghs N, Sicklick JK. Location of Gastrointestinal Stromal Tumor (GIST) in the Stomach Predicts Tumor Mutation Profile and Drug Sensitivity. Clin Cancer Res. 2021. Epub 20210729. doi: 10.1158/1078-0432.CCR-21-1221. PubMed PMID: 34326133.
    • Richelle A, Kellman BP, Wenzel AT, Chiang AWT, Reagan T, Gutierrez JM, Joshi C, Li S, Liu JK, Masson H, Lee J, Li Z, Heirendt L, Trefois C, Juarez EF, Bath T, Borland D, Mesirov JP, Robasky K, Lewis NE. Model-based assessment of mammalian cell metabolic functionalities using omics data. Cell Rep Methods. 2021;1(3). Epub 20210630. doi: 10.1016/j.crmeth.2021.100040. PubMed PMID: 34761247; PMCID: PMC8577426.
    • Maynard RE, Poore B, Hanaford AR, Pham K, James M, Alt J, Park Y, Slusher BS, Tamayo P, Mesirov J, Archer TC, Pomeroy SL, Eberhart CG, Raabe EH. TORC1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of MYC-driven medulloblastoma. Cancer Lett. 2021;504:137-45. Epub 20210208. doi: 10.1016/j.canlet.2021.02.001. PubMed PMID: 33571541.
    • Chen K, Ozturk K, Liefeld T, Reich M, Mesirov JP, Carter H, Fraley SI. A phenotypically supervised single-cell analysis protocol to study within-cell-type heterogeneity of cultured mammalian cells. STAR Protoc. 2021;2(2):100561. Epub 20210525. doi: 10.1016/j.xpro.2021.100561. PubMed PMID: 34095869; PMCID: PMC8165572.
    • Banerjee S, Yoon H, Ting S, Tang CM, Yebra M, Wenzel AT, Yeerna H, Mesirov JP, Wechsler-Reya RJ, Tamayo P, Sicklick JK. KIT(low) Cells Mediate Imatinib Resistance in Gastrointestinal Stromal Tumor. Mol Cancer Ther. 2021;20(10):2035-48. Epub 20210810. doi: 10.1158/1535-7163.MCT-20-0973. PubMed PMID: 34376580; PMCID: PMC8492542.
    • Benitez JA, Finlay D, Castanza A, Parisian AD, Ma J, Longobardi C, Campos A, Vadla R, Izurieta A, Scerra G, Koga T, Long T, Chavez L, Mesirov JP, Vuori K, Furnari F. Pten Deficiency Leads To Proteasome Addiction, A Novel Vulnerability In Glioblastoma. Neuro-oncology. 2021. Epub 2021/01/12. doi: 10.1093/neuonc/noab001. PubMed PMID: 33428749.
    Publications

Open Positions

  • Bioinformatics Scientist

    The Mesirov Lab at UC San Diego seeks an exceptional candidate who is passionate about accelerating the pace of cancer research through the analysis of genomic data and making sophisticated computational methods available to the research community at large through advanced, accessible software tools.

    • Learn More...

Upcoming events