Jill P. Mesirov, Ph.D.

UC San Diego, School of Medicine
UC San Diego, Moores Cancer Center

Professor of Medicine, Division of Medical Genetics;
Associate Vice Chancellor for Computational Health Sciences;
Co-Lead, Structural and Functional Cancer Genomics Research Program;

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Research in the Mesirov Lab focuses on cancer genomics applying machine-learning methods to functional data derived from patient tumors. The lab analyzes these molecular data to determine the underlying biological mechanisms of specific tumor subtypes, to stratify patients according to their relative risks of relapse, and to identify candidate compounds for new treatments. The overall goal is to treat patients as individuals specific to their tumors. Importantly, the lab is committed to the development of practical, accessible software tools to bring these methods to the general biomedical research community. The tools support over 500,000 users worldwide.

Featured News

    January 2021

    • Benitez JA, Finlay D, Castanza A, Parisian AD, Ma J, Longobardi C, Campos A, Vadla R, Izurieta A, Scerra G, Koga T, Long T, Chavez L, Mesirov JP, Vuori K, Furnari F. Pten Deficiency Leads To Proteasome Addiction, A Novel Vulnerability In Glioblastoma. Neuro-oncology. 2021. Epub 2021/01/12. doi: 10.1093/neuonc/noab001. PubMed PMID: 33428749.

    December 2020

    • Rusert JM, Juarez EF, Brabetz S, Jensen J, Garancher A, Chau LQ, Tacheva-Grigorova SK, Wahab S, Udaka YT, Finlay D, Seker-Cin H, Reardon B, Grobner S, Serrano J, Ecker J, Qi L, Kogiso M, Du Y, Baxter PA, Henderson JJ, Berens ME, Vuori K, Milde T, Cho YJ, Li XN, Olson JM, Reyes I, Snuderl M, Wong TC, Dimmock DP, Nahas SA, Malicki D, Crawford JR, Levy ML, Van Allen EM, Pfister SM, Tamayo P, Kool M, Mesirov JP, Wechsler-Reya RJ. Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma. Cancer research. 2020;80(23):5393-407. Epub 2020/10/14. doi: 10.1158/0008-5472.CAN-20-1655. PubMed PMID: 33046443; PMCID: PMC7718387.

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