MESIROV LAB


JILL P. MESIROV, Ph.D.

Professor of Medicine, Division of Medical Genetics;
Associate Vice Chancellor for Computational Health Sciences;
Co-Lead, Structural and Functional Cancer Genomics Research Program, Moores Cancer Center;
UC San Diego, School of Medicine

Jill Mesirov is associate vice chancellor for computational health sciences and professor of medicine at UC San Diego School of Medicine. As associate vice chancellor, Mesirov is responsible for the overarching strategy for computational health sciences and research computing at UC San Diego School of Medicine. She is a member of the UCSD Moores Cancer Center, where she serves as co-lead for the structural and functional genomics research program.

Mesirov is a computational scientist who has spent many years working in the area of high-performance computing on problems that arise in science, engineering, and business applications. Her research focuses on cancer genomics applying machine-learning methods to functional data derived from patient tumors. The lab analyzes this molecular data to determine the underlying biological mechanisms of specific tumor subtypes, to stratify patients according to their relative risks of relapse, and to identify candidate treatments. In addition, Mesirov is committed to the development of practical, accessible software tools to bring these methods to the general biomedical research community. Her tools support over half a million users worldwide.

Before moving to UC San Diego in 2015, Mesirov was associate director and chief informatics officer at the Broad Institute of MIT and Harvard, formerly the whitehead Institute/MIT Center for Genome Research, where she directed the Computational Biology and Bioinformatics Program and was a member of the Cancer Program steering committee. She previously served as manager of computational biology and bioinformatics in the Healthcare/Pharmaceutical Solutions Organization of IBM, director of research at Thinking Machines Corporation and has also held positions in the mathematics department at the University of California at Berkeley and served as associate executive director of the American Mathematical Society.

Mesirov is a fellow of the American Association for the Advancement of Science (AAAS), the American Mathematical Society (AMS), the International Society for Computational Biology (ISCB), and the Association for Women in Mathematics (AWM) where she formerly served as president. She was appointed as a founding member of Governor Jerry Brown’s California Precision Medicine Advisory Committee. The committee will advise the Governor's Office on all aspects of the state’s new precision medicine initiative and provide recommendations on further actions the public and private sectors can take to integrate precision medicine into health care.

Mesirov received her B.A. in mathematics from the University of Pennsylvania. She earned her M.A. and Ph.D. in mathematics from Brandeis University.

LAB MEMBERS


Mesirov Group
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Michael Reich

Director of Software Development

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Ted Liefeld

Lead Software Architect

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Helga Thorvaldsdóttir
(Broad Institute)

Lab Manager
Sr. Software Architect

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Jim Robinson, Ph.D.

Sr. Principal Software Engineer

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Lukas Chavez, Ph.D.

Adjunct Assistant Professor

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David Eby

Consultant

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Barbara Hill
(Broad Institute)

Sr. Test Engineer

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Thorin Tabor

Sr. Software Engineer

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Edwin Juárez, Ph.D.

Bioinformatics Programmer

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Anthony Castanza, Ph.D.

MSigDB Curator

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Dan Carlin, Ph.D.

Postdoc in the Ideker Lab

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Alex Wenzel

PhD Candidate

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Owen Chapman

PhD Candidate

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Sara Morimoto

Administrative Assistant

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Forrest Kim

Technical Assistant


STUDENTS & INTERNS

Name Program Project Title/Description Date
Miranda Song Undergraduate Intern May 2020 - Present
Jonathan Zamora UCSD Computer Science Creating a Seurat Module Suite in GenePattern May 2020 - Present
James Ni High School Intern June 2019 - Present
Jacob Gill STARS June - August 2020
Kyle Liu UCSD Statistics February - Sept 2020
Yingxi Lin UCSD Bioinformatics January - Sept 2020
Gabriel Diaz ENLACE June - August 2019
Hugo Gomez ENLACE June - August 2019
John Yin UCSD Mathematics Applying NMF with network regularization to transcriptomic data Jan - Dec 2019
Mengyi (Miko) Liu UCSD Bioinformatics Comparing batch correction algorithms for meta-analysis of single cell RNA-seq data Sept 2018 - June 2019
Chengze Shen Undergraduate Intern March - August 2018
Andy Zhang Regents Scholar Sept 2016 - May 2018
Xavier Gonzales Summer Internship Applying NMF with various constraints to transcriptomic data July - August 2018
Marylu Villa R. ENLACE Developing a suite of TCGA Data Importer Notebooks June - August 2018
Alejandra Ramos ENLACE Developing a suite of TCGA Data Importer Notebooks June - August 2018
Isaac Shanley Undergraduate Intern Helped develop IGV Reports October 2017 - June 2018

LAB ALUMNI

Name Title Description Years Worked
Arthur Liberzon, PhD Bioinformatics Scientist & MSigDB Curator (Broad Institute) Apr 2007 - May 2018
Sara Garamszegi, PhD Bioinformatics Scientist (Broad Institute) Jun 2014 - Mar 2017
James Jensen, PhD PhD Candidate Mar 2016 - May 2018
Clarence Mah Associate Computational Biologist Sept 2016 - Aug 2018
Kassi Kosnicki Associate Computational Biologist Sept 2016 - Feb 2017